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Sterile Liquid Filtration
Sterile Liquid filtration is critical for the pharmaceutical process in the manufacturing of drug components. The use of sterilizing grade filters in the final stage of the manufacturing process allows for a microorganism free solution. The filters need to be validated by bacterial challenge testing and subjected to a 100% non-destructed integrity tested to meet the regulatory compliance in a aseptic processing environment.
| Product | Membrane | Main Construction Material | Available Configuration | Grade | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PP | PES | PTFE | PVDF | Nylon | Glass Fiber | PFA | PP | PVDF | Capsule | Cartridge | Mini | Sterilizing | Bio-Burden Reduction | |||||||||||
| SuperDura → | • | • | • | • | ||||||||||||||||||||
| DureDunty → | • | • | • | • | ||||||||||||||||||||
| SterisPS → | • | • | • | • | ||||||||||||||||||||
| DN66T → | • | • | • | • | • | • | ||||||||||||||||||
| DN66TC → | • | • | • | • | • | • | ||||||||||||||||||
| DN66PC → | • | • | • | • | • | • | ||||||||||||||||||
| FluoroPV → | • | • | • | • | • | |||||||||||||||||||
| LHPVHBR → | • | • | • | • | ||||||||||||||||||||
| TeflonFlow → | • | • | • | • | ||||||||||||||||||||
| PFA → | • | • | • | • | ||||||||||||||||||||
| AET-F / AETI-F → | • | • | • | • | ||||||||||||||||||||
| APTF-T / APTFI-T → | • | • | • | • | ||||||||||||||||||||
| StarCaps → | • | • | • | • | • | • | • | • | • | • | ||||||||||||||
| Mini Filters → | • | • | • | • | • | • | • | • | • | |||||||||||||||
| LUPW Lab → | • | • | • | • | • | • | • | |||||||||||||||||
| Purcise → | • | • | • | • | • | |||||||||||||||||||
| Corevital → | • | • | • | • | • | |||||||||||||||||||
| Corevital APB → | • | • | • | • | • | |||||||||||||||||||
| Aegivast → | • | • | • | • | • | |||||||||||||||||||
| SafeSure → | • | • | • | • | • | |||||||||||||||||||
| ConSIEVE → | • | • | • | • | ||||||||||||||||||||
View Key Features & Benefits by Series | Sterile Liquid Filtration
SuperDura Series | ||||||
|---|---|---|---|---|---|---|
 | Super-Dura Filter Cartridges are designed for the majority of pharmaceutical liquids. These filters are composed of a hydrophilic PTFE membrane which provides excellent chemical and heat tolerance. | |||||
Hydrophilic PTFE membrane | Reqires no pre-wetting Excellent chemical compatibility especially for solvent-containing liquids Minimal preservative binding in ophthalmic solutions | |||||
Ultra clean | Clean membrane with very low gravimetric extractable | |||||
Designed for aqueous liquids | Install into housing dry to speed up filter changes and minimize downtime | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
Duredunty Series | ||||||
|---|---|---|---|---|---|---|
| Duredunty® Filter Cartridges use a unique double-layer PES membrane which provides excellent reliability in filtration and sterilization. They are designed for the filtration of a broad range of pharmaceutical products and the removal of particles, cysts, and bacteria in aqueous filtration applications, while providing superior flow rates and high particle removal efficiency when compared to other sterilizing grade filter cartridges. | |||||
Double-layer hydrophilic PES membrane | Requires no pre-wetting Asymmetric pre-filter layer provides longer service life and lower filtration cost Broad chemical compatibility (pH 1-14) The double-layer provides added safety when compared to normal PES filters Design allows for multiple autoclave cycles and extended use | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
SterisPS Series | ||||||
|---|---|---|---|---|---|---|
| SteriPS® Filter Cartridges are specially designed to provide a reliable sterilization solution at an economical cost. Hydrophilic PES membrane cartridges require no pre-wetting and are ready to use. In addition, these filters provide excellent performance for pharmaceutical applications. | |||||
Hydrophilic PES membrane | Requires no pre-wetting Low diffusion flow High surface area provides excellent flow rates and extended service life while maintaining high bacteria removal efficiency Low protein binding | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
DN66T Series | ||||||
|---|---|---|---|---|---|---|
| DN66T Filter Cartridges are composed of a dual layer of hydrophilic Nylon 66 membrane. These filters are specifically designed for bio-burden reduction and the final filtration of a wide range of pharmaceutical and biological solutions. | |||||
Hydrophilic Nylon 66 membrane | Ideal for rapid wetability High bubble point ensures a more reliable retention efficiency Low pressure drop and high flow rates Dual layer ensures longer service life, with added security | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
DN66TC Series | ||||||
|---|---|---|---|---|---|---|
| DN66TC Filter Cartridges are composed of a dual layer of hydrophilic Nylon 66 membrane. These filters are specifically designed for bio-burden reduction and the final filtration of a wide range of pharmaceutical and biological solutions. The Nylon 66 membrane provides enhanced retention of fine particles. | |||||
Hydrophilic Nylon 66 membrane | Lower bubblepoint for faster flow rates Ideal for rapid wetability 100% integrity tested Low pressure drop and high flow rates Dual layer ensures longer service life, with added security | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
DN66PC Series | ||||||
|---|---|---|---|---|---|---|
| DN66PC Filter Cartridges are composed of a dual layer of hydrophilic positively-charged Nylon 66 membrane. These filters are specifically designed for bio-burden reduction and the final filtration of a wide range of pharmaceutical and biological solutions. The Nylon 66 membrane with positive charged Zeta particles provides enhanced retention of fine particles such as endotoxins. | |||||
Hydrophilic Nylon 66 membrane with Zeta particles | Positively charged to minimize endotoxins Ideal for rapid wetability High bubble point ensures a more reliable retention efficiency Low pressure drop and high flow rates Dual layer ensures longer service life, with added security | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
FluoroPV Series | ||||||
|---|---|---|---|---|---|---|
| FluoroPV® Filter Cartridges are composed of a unique hydrophilic polyvinylidene fluoride (PVDF) membrane characterized by low extractable and protein binding. They are suitable for the sterilized filtration of pharmaceutical liquids including ophthalmic liquids, biological and other diluted preservative solutions. | |||||
Hydrophilic PVDF Membrane | Low extractable and protein binding Broad chemical compatibility and temperature resistance Excellent durability proven by testing forward/reverse pulse up to 100x Design allows for multiple autoclave cycles and extended use | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
LHPVHBR Series | ||||||
|---|---|---|---|---|---|---|
| LHPVHBR Filter Cartridges feature a positive-charged Zeta membrane that removes a significant level of particles and endotoxins. They are suitable for the sterilized filtration of pharmaceutical liquids, including ophthalmic liquids, biological, and other diluted preservative solutions. These filters are available as single-layer and double-layer hydrophilic construction. | |||||
Modified PVDF membrane with positive-charged Zeta particles with polypropylene construction (supports) | Low extractables with low protein binding Positive-charged Zeta particles absorb small particles and endotoxins Hydrophilic membrane with broad chemical compatibility and temperature resistance Excellent durability, proven by testing forward/reverse pulses up to 100x | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
TeflonFlow Series | ||||||
|---|---|---|---|---|---|---|
| TeflonFlow Filter Cartridges are composed of a hydrophobic PTFE membrane with polypropylene construction. The filter is highly resistant to organic & inorganic corrosion. These filters are ideally suited for the sterile filtration of solvents, corrosive and oxidized liquids. | |||||
PTFE membrane with polypropylene construction (supports) | Inherently hydrophobic Broad chemical compatibility High tolerance for aggressive acids and bases High flow rates Low extractables | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
PFA Series | ||||||
|---|---|---|---|---|---|---|
| PFA Filter Cartridges are composed of an expanded PTFE membrane and PFA cage, core, and support. These filters are specially designed for applications with extremely aggressive environments, including strong acids, alkalis, and solvents and high temperature.Validated sterile grade is also available, named PFA-T, which is highly recommended for strict pharmaceutical applications. | |||||
100% fluoropolymer construction | High filtration performance including high flow rates and low pressure drop Ideal for use with strong acids, alkalis, solvents, and high-temperature applications Excellent durability | |||||
Available pre-wet | Allows for rapid return to process flow conditions. Eliminating prewetting for aqueous applications | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
AET/AETI Series | ||||||
|---|---|---|---|---|---|---|
| AET Filter Cartridges are composed of a hydrophobic PTFE membrane and ECTFE core, cage, and support, making it suitable for use in strong acid and solvent filtration.AETI Filter Cartridges have a hydrophilic PTFE membrane which is specially designed for aggressive water-based filtration conditions.AET and AEIT Filter Cartridges are recommended for particle removal in aggressive pharmaceutical applications. | |||||
100% fluoropolymer construction | High filtration performance including high flow rates and low pressure drop Ideal for use with strong acids, and solvent filtration 0.22 μm rating's retention efficiency up to 99.99999% Available in both hydrophobic and hydrophilic PTFE media Broad chemical compatibility | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
APTF-T/AETFI-T Series | ||||||
|---|---|---|---|---|---|---|
| APTF-T Filter Cartridges are composed of a an expanded hydrophobic PTFE membrane, ECTFE support, and PVDF cage and core making it suitable to use in strong acid and solvent filtration. APTFI-T Filter Cartridges are composed of a hydrophilic PTFE membrane which is specially designed for aggressive water-based filtration conditions. | |||||
100% fluoropolymer construction | High filtration performance including high flow rates and low pressure drop Ideal for use with strong acids,and solvent filtration 0.22 μm rating's retention efficiency up to 99.99999% Available in both hydrophobic and hydrophilic PTFE media Broad chemical compatibility | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
Starcaps Series | ||||||
|---|---|---|---|---|---|---|
| StarCaps Capsule Filters are self-contained, ready-to-use capsule filters. Available in varying sizes and filter media including depth filters, liquid sterile-grade filters and gas filters, they were developed to meet a wide range of pharmaceutical filtration requirements from R&D to production.The StarCaps Capsule Filter Series eliminates cleaning validation requirements when compared to the traditional filter cartridge and housing combination. | |||||
Available in a variety of medias and configurations | Capsules available for a wide range of application requirements, from R&D to production usage | |||||
Thermal welding technology | No adhesive resins to ensure capsule filter's cleanliness and long-use pressure endurance | |||||
Sanitary flange and hose barb connections | Provide clean and easy connection | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
Mini Cartridge Filter Series | ||||||
|---|---|---|---|---|---|---|
| Cobetter® Mini Cartridge Filters area available in varying sizes and filter media including depth filters, liquid sterile-grade filters and gas filters, they were developed to meet a wide range of pharmaceutical, biological, and food & beverage filtration requirements. The Mini Cartridge Filter Series contains a wide-range of filtration media options (PTFE, PES, PVDF, and PP), in a variety of filter sizes and effective filtration areas. | |||||
Available in a variety of filtration media (PTFE/PES/PVDF/PP) | Filters available with media options to match the specific flow, retention, and performance requirements of low-flow pharmaceutical, biological, and food & beverage filtration applications | |||||
No surfactants or binders | Clean, low-extractable filters | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
LUPW Lab Capsule Filter Series | ||||||
|---|---|---|---|---|---|---|
| Cobetter® LUPW Lab Capsule Filters are disposable sterile, and read-to-use membrane filtration capsules. With inside membrane available in hydrophilic polyethersulfone (PES) membrane, Nylon 66 membrane, PVDF membrane, or PTFE membrane. These filters are ideally suited for the sterile filtration of purified water, buffers, infusion solutions, tissue culture solutions, and protein solutions. | |||||
Available in four filter media options with low hold-up volume, high throughput, and high flow rates | Hydrophilic PES Membrane: Instant wetting in aqueous solutions Nylon 66 Membrane: Ideal for rapid wetability, high bubble point pressure reliable retention efficiency, lower pressure drop and high flow rates Hydrophilic PVDF Membrane: For added chemical resistance Hydrophilic PTFE Membrane: High flow rates, low pressure drops for applicable solutions | |||||
Thermal welding technology | No adhesive resins to ensure capsule filter's cleanliness and long-use pressure endurance | |||||
Multiple connection options | Available in a variety of connector configurations to allow easy connection in most common applications | |||||
Quality Assurance | Manufactured in a Class 10,000 Clean room in a facility which adheres to ISO 9001 Practices | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
Purcise Series | ||||||
|---|---|---|---|---|---|---|
| Purcise® Series Filters are available in a variety of hydrophilic polyethersulfone (PES) media constructions to meet the needs of bioburden reduction, pre-filtration, steam-in-place requirements, sterilization requirements, for a wide range of critical processing requirements. | |||||
Muliple filtration media | CHC: Special wrapped multiple polypropylene layers, nominally rated, provides long service life and high flow rate CHT: Multiple (5-10) layers of polypropylene media: provides high retention with no adhesives or surfactants CHE: Double-layer polypropylene, outer layer of fine fibers, inner layer of nanofibers: high retention efficiency | |||||
Multiple configurations | Allows for efficient use of the filtration area, minimizing wasted filtration. | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
Corevital Series | ||||||
|---|---|---|---|---|---|---|
| Corevital® Series Filters are constructed of dual-layer hydrophilic Polyvinylidene Fluoride PVDF media to meet the needs of bioburden reduction, pre-filtration, sterilization requirements, for a wide range of critical processing requirements. | |||||
SMD - Dual layer PVDF | Sterilizing grade High flow rates Low extractables | |||||
PMD - Dual layer PVDF | Prefiltration (Biological reduction grade) High flow rates Low extractables Efficient bacteria and particulate retention | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
Corevital APB Series | ||||||
|---|---|---|---|---|---|---|
| Corevital® APB Series Filters are constructed of hydrophobic Polyvinylidene Fluoride (PVDF) media to meet the needs of sterilization requirements, for a wide range of critical gas/venting processing requirements. | |||||
Hydrophobic PVDF media | Sterilizing grade High flow rates Low extractables Efficient bacteria and particulate retention | |||||
Multiple connection options | Available in a variety of filter sizes, configurations, and connector configurations to allow easy connection in most common applications. | |||||
Quality Assurance | Manufactured in a facility which adheres to ISO 9001 Practices. | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
Aegivast Series | ||||||
|---|---|---|---|---|---|---|
| Aegivast® Series Filters are available in a variety of disc, capsule, and cartridge configurations to match the flow, lifetime, and configuration requirements of multiple gas process applications.The hydrophobic PTFE allows for high retention rates with low pressure differential. These filters are ideal for vent filters for fermentors, tanks, bio bags, and other applications where sterility barriers are needed. | |||||
Hydrophobic Polytetrafluoroethylene (PTFE) with Polyester or Polypropylene supports | Sterilizing grade High flow rates Low pressure drop | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
SafeSure Series | ||||||
|---|---|---|---|---|---|---|
| SafeSure® Series Filters are available in a variety of capsule and cartridge configurations to match the flow, lifetime, and configuration requirements of multiple gas process applications. The hydrophobic PTFE allows for high retention rates with low pressure differential. These filters are ideal for vent filters for fermentors, tanks, bio bags, and other applications where sterility barriers are needed. | |||||
Hydrophobic Polytetrafluoroethylene (PTFE) with Polypropylene supports | Sterilizing grade High flow rates Low pressure drop Higher temperature | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||
Consieve UET TFF Cassettes Series | ||||||
|---|---|---|---|---|---|---|
| Consieve® UET Tangential Flow Filtration (TFF) Cassette membranes have high retention efficiency and are easy to clean/install. The cassettes are available in a wide range of configurations Due to their design, it is easy to amplify/increase cassette stacking to meet specific process requirements. The inner gaskets make installation/ cleaning/storage/replacement quick and easy. The configurable low working volume and high efficiency ensure cost-effective product yields.Stainless steel holders and complete custom systems enable use of the TFF cassettes to meet a multitude of process and application requirements. | |||||
Specs, Flow Curves, and Part Number Configurator → | ||||||