Pharmaceutical Filtration Products

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Sterile Liquid Filtration

Sterile Liquid filtration is critical for the pharmaceutical process in the manufacturing of drug components. The use of sterilizing grade filters in the final stage of the manufacturing process allows for a microorganism free solution. The filters need to be validated by bacterial challenge testing and subjected to a 100% non-destructed integrity tested to meet the regulatory compliance in a aseptic processing environment.

ProductMembraneMain Construction MaterialAvailable ConfigurationGrade
PPPESPTFEPVDFNylonGlass FiberPFAPPPVDFCapsuleCartridgeMiniSterilizingBio-Burden Reduction
SuperDura →
DureDunty →
SterisPS →
DN66T →
DN66PC →
FluoroPV →
LHPVHBR →
TeflonFlow →
PFA →
AET-F / AETI-F →
APTF-T / APTFI-T →
StarCaps →
Mini Filters →
LUPW Lab →
Purcise →
Corevital →
Corevital APB →
Aegivast →
Consieve →

View Key Features & Benefits by Series | Sterile Liquid Filtration

SuperDura Series

Cobetter Pharma Filtration

Super-Dura Filter Cartridges are designed for the majority of pharmaceutical liquids. These filters are composed of a hydrophilic PTFE membrane which provides excellent chemical and heat tolerance.

Hydrophilic PTFE membrane

Reqires no pre-wetting
Excellent chemical compatibility especially for solvent-containing liquids
Minimal preservative binding in ophthalmic solutions

Ultra clean

Clean membrane with very low gravimetric extractable

Designed for aqueous liquids

Install into housing dry to speed up filter changes and minimize downtime

Specs, Flow Curves, and Part Number Configurator →

Duredunty Series

Cobetter Pharma Filtration

Duredunty® Filter Cartridges use a unique double-layer PES membrane which provides excellent reliability in filtration and sterilization. They are designed for the filtration of a broad range of pharmaceutical products and the removal of particles, cysts, and bacteria in aqueous filtration applications, while providing superior flow rates and high particle removal efficiency when compared to other sterilizing grade filter cartridges.

Double-layer hydrophilic PES membrane

Requires no pre-wetting
Asymmetric pre-filter layer provides longer service life and lower filtration cost
Broad chemical compatibility (pH 1-14)
The double-layer provides added safety when compared to normal PES filters
Design allows for multiple autoclave cycles and extended use

Specs, Flow Curves, and Part Number Configurator →

SterisPS Series

Cobetter Pharma Filtration

SteriPS® Filter Cartridges are specially designed to provide a reliable sterilization solution at an economical cost. Hydrophilic PES membrane cartridges require no pre-wetting and are ready to use. In addition, these filters provide excellent performance for pharmaceutical applications.

Hydrophilic PES membrane

Requires no pre-wetting
Low diffusion flow
High surface area provides excellent flow rates and extended service life while maintaining high bacteria removal efficiency
Low protein binding

Specs, Flow Curves, and Part Number Configurator →

DN66T Series

Cobetter Pharma Filtration

DN66T Filter Cartridges are composed of a dual layer of hydrophilic Nylon 66 membrane. These filters are specifically designed for bio-burden reduction and the final filtration of a wide range of pharmaceutical and biological solutions.

Hydrophilic Nylon 66 membrane

Ideal for rapid wetability
High bubble point ensures a more reliable retention efficiency
Low pressure drop and high flow rates
Dual layer ensures longer service life, with added security

Specs, Flow Curves, and Part Number Configurator →

DN66PC Series

Cobetter Pharma Filtration

DN66PC Filter Cartridges are composed of a dual layer of hydrophilic positively-charged Nylon 66 membrane. These filters are specifically designed for bio-burden reduction and the final filtration of a wide range of pharmaceutical and biological solutions. The Nylon 66 membrane with positive charged Zeta particles provides enhanced retention of fine particles such as endotoxins.

Hydrophilic Nylon 66 membrane with Zeta particles

Positively charged to minimize endotoxins Ideal for rapid wetability
High bubble point ensures a more reliable retention efficiency
Low pressure drop and high flow rates
Dual layer ensures longer service life, with added security

Specs, Flow Curves, and Part Number Configurator →

FluoroPV Series

Cobetter Pharma Filtration

FluoroPV® Filter Cartridges are composed of a unique hydrophilic polyvinylidene fluoride (PVDF) membrane characterized by low extractable and protein binding. They are suitable for the sterilized filtration of pharmaceutical liquids including ophthalmic liquids, biological and other diluted preservative solutions.

Hydrophilic PVDF Membrane

Low extractable and protein binding
Broad chemical compatibility and temperature resistance
Excellent durability proven by testing forward/reverse pulse up to 100x
Design allows for multiple autoclave cycles and extended use

Specs, Flow Curves, and Part Number Configurator →

LHPVHBR Series

Cobetter Pharma Filtration

LHPVHBR Filter Cartridges feature a positive-charged Zeta membrane that removes a significant level of particles and endotoxins. They are suitable for the sterilized filtration of pharmaceutical liquids, including ophthalmic liquids, biological, and other diluted preservative solutions. These filters are available as single-layer and double-layer hydrophilic construction.

Modified PVDF membrane with positive-charged Zeta particles with polypropylene construction (supports)

Low extractables with low protein binding
Positive-charged Zeta particles absorb small particles and endotoxins
Hydrophilic membrane with broad chemical compatibility and temperature resistance
Excellent durability, proven by testing forward/reverse pulses up to 100x

Specs, Flow Curves, and Part Number Configurator →

TeflonFlow Series

Cobetter Pharma Filtration

TeflonFlow Filter Cartridges are composed of a hydrophobic PTFE membrane with polypropylene construction. The filter is highly resistant to organic & inorganic corrosion. These filters are ideally suited for the sterile filtration of solvents, corrosive and oxidized liquids.

PTFE membrane with polypropylene construction (supports)

Inherently hydrophobic
Broad chemical compatibility
High tolerance for aggressive acids and bases High flow rates
Low extractables

Specs, Flow Curves, and Part Number Configurator →

PFA Series

Cobetter Pharma FiltrationPFA Filter Cartridges are composed of an expanded PTFE membrane and PFA cage, core, and support. These filters are specially designed for applications with extremely aggressive environments, including strong acids, alkalis, and solvents and high temperature.Validated sterile grade is also available, named PFA-T, which is highly recommended for strict pharmaceutical applications.

100% fluoropolymer construction

High filtration performance including high flow rates and low pressure drop
Ideal for use with strong acids, alkalis, solvents, and high-temperature applications
Excellent durability

Available pre-wet

Allows for rapid return to process flow conditions. Eliminating prewetting for aqueous applications

Specs, Flow Curves, and Part Number Configurator →

AET/AETI Series

Cobetter Pharma FiltrationAET Filter Cartridges are composed of a hydrophobic PTFE membrane and ECTFE core, cage, and support, making it suitable for use in strong acid and solvent filtration.AETI Filter Cartridges have a hydrophilic PTFE membrane which is specially designed for aggressive water-based filtration conditions.AET and AEIT Filter Cartridges are recommended for particle removal in aggressive pharmaceutical applications.

100% fluoropolymer construction

High filtration performance including high flow rates and low pressure drop
Ideal for use with strong acids, and solvent filtration
0.22 μm rating's retention efficiency up to 99.99999%
Available in both hydrophobic and hydrophilic PTFE media
Broad chemical compatibility

Specs, Flow Curves, and Part Number Configurator →

 APTF-T/AETFI-T Series

Cobetter Pharma Filtration

APTF-T Filter Cartridges are composed of a an expanded hydrophobic PTFE membrane, ECTFE support, and PVDF cage and core making it suitable to use in strong acid and solvent filtration. APTFI-T Filter Cartridges are composed of a hydrophilic PTFE membrane which is specially designed for aggressive water-based filtration conditions.

100% fluoropolymer construction

High filtration performance including high flow rates and low pressure drop
Ideal for use with strong acids,and solvent filtration
0.22 μm rating's retention efficiency up to 99.99999%
Available in both hydrophobic and hydrophilic PTFE media
Broad chemical compatibility

Specs, Flow Curves, and Part Number Configurator →

Starcaps Series

Cobetter Pharma FiltrationStarCaps Capsule Filters are self-contained, ready-to-use capsule filters. Available in varying sizes and filter media including depth filters, liquid sterile-grade filters and gas filters, they were developed to meet a wide range of pharmaceutical filtration requirements from R&D to production.The StarCaps Capsule Filter Series eliminates cleaning validation requirements when compared to the traditional filter cartridge and housing combination.

Available in a variety of medias and configurations

Capsules available for a wide range of application requirements, from R&D to production usage

Thermal welding technology

No adhesive resins to ensure capsule filter's cleanliness and long-use pressure endurance

Sanitary flange and hose barb connections

Provide clean and easy connection

Specs, Flow Curves, and Part Number Configurator →

Mini Cartridge Filter Series

Cobetter Pharma FiltrationCobetter® Mini Cartridge Filters area available in varying sizes and filter media including depth filters, liquid sterile-grade filters and gas filters, they were developed to meet a wide range of pharmaceutical, biological, and food & beverage filtration requirements. The Mini Cartridge Filter Series contains a wide-range of filtration media options (PTFE, PES, PVDF, and PP), in a variety of filter sizes and effective filtration areas.

Available in a variety of filtration media (PTFE/PES/PVDF/PP)

Filters available with media options to match the specific flow, retention, and performance requirements of low-flow pharmaceutical, biological, and food & beverage filtration applications

No surfactants or binders

Clean, low-extractable filters

Specs, Flow Curves, and Part Number Configurator →

LUPW Lab Capsule Filter Series

Cobetter Pharma FiltrationCobetter® LUPW Lab Capsule Filters are disposable sterile, and read-to-use membrane filtration capsules. With inside membrane available in hydrophilic polyethersulfone (PES) membrane, Nylon 66 membrane, PVDF membrane, or PTFE membrane. These filters are ideally suited for the sterile filtration of purified water, buffers, infusion solutions, tissue culture solutions, and protein solutions.

Available in four filter media options with low hold-up volume, high throughput, and high flow rates

Hydrophilic PES Membrane: Instant wetting in aqueous solutions
Nylon 66 Membrane: Ideal for rapid wetability, high bubble point pressure reliable retention efficiency, lower pressure drop and high flow rates
Hydrophilic PVDF Membrane: For added chemical resistance
Hydrophilic PTFE Membrane: High flow rates, low pressure drops for applicable solutions

Thermal welding technology

No adhesive resins to ensure capsule filter's cleanliness and long-use pressure endurance

Multiple connection options

Available in a variety of connector configurations to allow easy connection in most common applications

Quality Assurance

Manufactured in a Class 10,000 Clean room in a facility which adheres to ISO 9001 Practices

Specs, Flow Curves, and Part Number Configurator →

Purcise Series

Cobetter Pharma FiltrationPurcise® Series Filters are available in a variety of hydrophilic polyethersulfone (PES) media constructions to meet the needs of bioburden reduction, pre-filtration, steam-in-place requirements, sterilization requirements, for a wide range of critical processing requirements.

Muliple filtration media

CHC: Special wrapped multiple polypropylene layers, nominally rated, provides long service life and high flow rate
CHT: Multiple (5-10) layers of polypropylene media: provides high retention with no adhesives or surfactants
CHE: Double-layer polypropylene, outer layer of fine fibers, inner layer of nanofibers: high retention efficiency

Multiple configurations

Allows for efficient use of the filtration area, minimizing wasted filtration.

Specs, Flow Curves, and Part Number Configurator →

Corevital Series

Cobetter Pharma FiltrationCorevital® Series Filters are constructed of dual-layer hydrophilic Polyvinylidene Fluoride PVDF media to meet the needs of bioburden reduction, pre-filtration, sterilization requirements, for a wide range of critical processing requirements.

SMDDual layer PVDF

Sterilizing grade
High flow rates
Low extractables

PMD - Dual layer PVDF

Prefiltration (Biological reduction grade)
High flow rates
Low extractables
Efficient bacteria and particulate retention

Specs, Flow Curves, and Part Number Configurator →

Corevital APB Series

Cobetter Pharma FiltrationCorevital® APB Series Filters are constructed of hydrophobic Polyvinylidene Fluoride (PVDF) media to meet the needs of sterilization requirements, for a wide range of critical gas/venting processing requirements.

Hydrophobic PVDF media

Sterilizing grade
High flow rates
Low extractables
Efficient bacteria and particulate retention

Multiple connection options

Available in a variety of filter sizes, configurations, and connector configurations to allow easy connection in most common applications.

Quality Assurance

Manufactured in a facility which adheres to ISO 9001 Practices.

Specs, Flow Curves, and Part Number Configurator →

Aegivast Series

Cobetter Pharma FiltrationAegivast® Series Filters are available in a variety of disc, capsule, and cartridge configurations to match the flow, lifetime, and configuration requirements of multiple gas process applications.The hydrophobic PTFE allows for high retention rates with low pressure differential. These filters are ideal for vent filters for fermentors, tanks, bio bags, and other applications where sterility barriers are needed.

AFM (Capsules & Cartridges) - Hydrophobic Polytetrafluoroethylene (PTFE) with Polypropylene supports

Sterilizing grade
High flow rates
Low pressure drop
Higher temperature

ACE (Disc Filters)Hydrophobic Polytetrafluoroethylene (PTFE) with Polyester or Polypropylene supports

Sterilizing grade
High flow rates
Low pressure drop

Specs, Flow Curves, and Part Number Configurator →

Consieve UET TFF Cassettes Series

Cobetter Pharma FiltrationConsieve® UET Tangential Flow Filtration (TFF) Cassette membranes have high retention efficiency and are easy to clean/install. The cassettes are available in a wide range of configurations Due to their design, it is easy to amplify/increase cassette stacking to meet specific process requirements. The inner gaskets make installation/ cleaning/storage/replacement quick and easy. The configurable low working volume and high efficiency ensure cost-effective product yields.Stainless steel holders and complete custom systems enable use of the TFF cassettes to meet a multitude of process and application requirements.

Specs, Flow Curves, and Part Number Configurator →

Liquid Prefiltration or Bio-Burden Reduction

Prefiltration and Bio-burden reduction filters are utilized to minimize the amount of particulate matter or bacteria living in the solutions that is being filtered. This reduction of this material allows for longer life of the final filters that are typically tighter and at a increase costs. The use of these filters acts as a cost savings process to protect the final filters from the larger particles or masses that would prematurely plug the filter. The throughput of the systems also increases because of these filters take the load of the larger particles off the final filters. Prefilters or Bio-burden reduction filters are recommended in the part of the process where 100% of the retention of contaminates above their rated pore size is not required.

ProductMembraneMain MaterialAvailable ConfigurationGrade
PPPESPTFEPVDFNylonGlass FiberSpecialtyPPCapsuleCartridgeMiniDiscSterilizingBio-Burden Reduction
Advanlife →
MultiPoly →
PoliFlow →
Absoguard →
Carbon Block Filter→
GlassFlow →
StarCaps →
Mini Filters →
Roheap CSD →
Greclary →
Excesal →

View Key Features & Benefits by Series | Liquid Prefiltration or Bio-Burden Reduction

AdvanLife Series

Cobetter Pharma Filtration

AdvanLife® Filter Cartridges feature a unique single-layer asymmetric hydrophilic polyethersulfone membrane. These filters are recommended as bio-burden reduction filter as they provide the final stage sterilizing-grade filtration with additional protection to increase its service life.

Asymmetric PES membrane

Highly asymmetric polyethersulfone membrane allows for a high particle holding capacity and longer service life
Provides broad chemical compatibility
High flow rates and low pressure drops

Specs, Flow Curves, and Part Number Configurator →

MultiPoly Series

Cobetter Pharma FiltrationMultiPoly® Filter Cartridges are composed of multi-layered pleated polypropylene. These filters have a depth filter design that includes graded pore size and high contaminant holding capacity which eliminates contaminants (including gels and agglomerates) in highly viscous liquids, and avoids filter surface plugging. The graded pore size distribution from coarse (upstream) to fine (downstream) removes particles gradually and extends the filter’s service life making it especially suited for suspended particulates, colloids, and viscous liquids.

Quality Assurance

These products are manufactured in a facility which adheres to ISO 9001 Practices.

TOC / Conductivity at 25°C

Autoclaved filter effluent meets the USP <643> for Total Organic Carbon and USP <645> for Water Conductivity per WFI requirements after a UPW flush of specified volume.

Particle Shedding

Autoclaved filter effluent meets the requirements in USP <788> for large volume injections.

Non-Fiber Releasing

Component materials meet the criteria for a “Non-fiber-releasing filter” as defined in 21 CFR 210.3 (b) (6)

Bacterial Endotoxin

Aqueous extraction of autoclaved filter contains < 0.25 EU/mL as determined by Limulus; Amebocyte Lysate (LAL), USP <85>.

USP <87> Cytotoxicity

Meet the requirement of USP <87> In Vitro Cytotoxicity Test.

USP <88> Biological Toxicity

Meet the criteria of the USP <88> Biological Reactivity Test for Class VI-121°C plastics.

Indirect Food Additive

All component materials meet the FDA Indirect Food Additive requirements cited in 21 CFR 177–182, and EU framework regulation [1935/2004/EC].

Specs, Flow Curves, and Part Number Configurator →

PoliFlow Series

Cobetter Pharma FiltrationPoliFlow® Filter Cartridges are composed entirely of pleated polypropylene microfi ber which provides great fi ltration performance with a low cost. Characteristics include high flow rates, high contaminant holding capacity and fi ltration effi ciency making it the ideal solution for the pre-fi ltration of liquids.

All Polypropylene construction

Broad chemical compatibility makes it suitable for acids, bases, and solvents
High filtration efficiency
Pleated surface area provides superior flow rate and extended service life
100% thermally-welded design eliminates the need for adhesives which can be a contamination source
Available in nominal ratings from 0.2μm to 20μm for precise particle removal

Specs, Flow Curves, and Part Number Configurator →

Absoguard Series

Cobetter Pharma FiltrationAbsoguard® Filter Cartridges are all-polypropylene pleated depth filters. Characteristics include 99% efficient multilayer media with high particle holding capacity, long service life, and extremely high flow rates. They proivde efficeint retention of particles in critical applications.

Two-layer pleated construction

Provides superior flow rate and extended service life.

Nanofiber media

Provides excellent particle retention and filtration perform.

All-polypropylene construction

100% polypropylene construction provides wide chemical compatibility.

Specs, Flow Curves, and Part Number Configurator →

Carbon Block/Fiber Series

Cobetter Pharma FiltrationCobetter Carbon Block/Fiber Filters are comprised of activate carbon and carbon fiber. The activated carbon effectively absorbs macromolecular pigments, organic matter, heavy metals, and particles. The carbon fiber provides good removal capabilities for Total Organic Carbon (TOC) in water.

Activated Carbon and Activated Carbon Fibers

Provides a three-dimensional mesh structure that purifies and provides decolorization processing.

Polypropylene Non-woven Fabric Outer Layer

Provides additional protection for particulate removal.

Available in Standard Lengths and Connections

Available from in 5, 10, 20, and 40 inch lengths, in DOE, 226, and 222 configurations (see ordering information).

Specs, Flow Curves, and Part Number Configurator →

GlassFlow Series

Cobetter Pharma FiltrationGlassFlow® Filter Cartridges are composed of super-fine glass fiber media with a pre-layer constructed of polypropylene for use during pre-filtration and final filtration. Glass fiber media has an inherently absorptive characteristic that enhances filter retention capability. These filters are ideally suited in the filtration of liquids containing gels, lipids, and protein

Super-fine glass micro-fiber membrane with built-in polypropylene pre-filtration layer

High porosity for high flow rates and low pressure drops
>97% particle retention efficiency at rated pore size
Stiff structure of glass micro-fiber media provides high flow rate
Glass fiber media has high contaminant holding capacity and inherently adsorptive effect which features its gel removal ability
Extremely good chemical compatibility

Specs, Flow Curves, and Part Number Configurator →

Starcaps Series

Cobetter Pharma FiltrationStarCaps Capsule Filters are self-contained, ready-to-use capsule filters. Available in varying sizes and filter media including depth filters, liquid sterile-grade filters and gas filters, they were developed to meet a wide range of pharmaceutical filtration requirements from R&D to production.The StarCaps Capsule Filter Series eliminates cleaning validation requirements when compared to the traditional filter cartridge and housing combination.

Available in a variety of medias and configurations

Capsules available for a wide range of application requirements, from R&D to production usage

Thermal welding technology

No adhesive resins to ensure capsule filter's cleanliness and long-use pressure endurance

Sanitary flange and hose barb connections

Provide clean and easy connection

Specs, Flow Curves, and Part Number Configurator →